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To meet the diagnostic criteria for pEDS, a person must meet: Major criterion 1 AND two other major criteria AND one minor criterion OR Major criterion 2 AND two other major criteria AND one minor criterion Major Criteria Severe and intractable periodontitis of early onset (childhood or adolescence) Lack of attached gingiva Pretibial plaques Family history of a first-degree relative who meets the clinical diagnostic criteria for pEDS Minor Criteria Easy bruising Joint hypermobility, mostly distal joints Skin hyperextensibility and fragility, abnormal scarring (wide or atrophic) Increased rate of infections Hernias Marfanoid facial features Acrogeria Prominent vasculature Spondylodysplastic EDS (spEDS) If a person meets the diagnostic criteria for spEDS, genetic testing should be done to confirm the diagnosis

AminoMultiPlex contains four essential amino acids: These amino acids participate in foundational processes associated with recovery, strength, energy metabolism and overall vitality

doi:10.1016/j.pmr.2019.07.003 Platelet-rich plasma therapy (PRP)

Ayurvedic management is applied alongside necessary medical care to ensure safety and optimize outcomes

As mentioned, vitamin B12 plays a significant role in the growth and operation of brain and nerve cells

Importantly, Botox can help to prevent migraine headaches before they start